前段時間，美國加州理工學(xué)院一研究團隊研發(fā)了一種可檢測激光雕刻的可汗液中的尿酸和的酪氨酸的可穿戴傳感器，并且在《自然—生物技術(shù)》上進行了發(fā)表。
研究人員報道了一個完全激光雕刻的傳感器，可同時進行汗液采樣、化學(xué)傳感和生命體征監(jiān)測。研究人員證明了對溫度、呼吸頻率以及低濃度尿酸和酪氨酸、痛風(fēng)和代謝紊亂等疾病相關(guān)分析物的持續(xù)檢測。在運動后和富含蛋白質(zhì)的飲食之后，研究人員在經(jīng)過身體訓(xùn)練和未經(jīng)訓(xùn)練的受試者中測試該設(shè)備的性能。
研究人員還通過富含嘌呤的膳食改變評估其在痛風(fēng)監(jiān)測患者和健康對照中的功能。痛風(fēng)患者的汗液中尿酸水平高于健康個體，血清中也觀察到類似趨勢。
據(jù)悉，穿戴式汗液傳感器可用于持續(xù)測量有用的生物標(biāo)志物。但是，當(dāng)前的傳感器不能準(zhǔn)確地檢測低的分析物濃度、缺乏多模式感測或難以大規(guī)模制造。
附：英文原文
Title: A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat
Author: Yiran Yang, Yu Song, Xiangjie Bo, Jihong Min, On Shun Pak, Lailai Zhu, Minqiang Wang, Jiaobing Tu, Adam Kogan, Haixia Zhang, Tzung K. Hsiai, Zhaoping Li, Wei Gao
Issue&Volume: 2019-11-25
Abstract: Wearable sweat sensors have the potential to provide continuous measurements of useful biomarkers. However, current sensors cannot accurately detect low analyte concentrations, lack multimodal sensing or are difficult to fabricate at large scale. We report an entirely laser-engraved sensor for simultaneous sweat sampling, chemical sensing and vital-sign monitoring. We demonstrate continuous detection of temperature, respiration rate and low concentrations of uric acid and tyrosine, analytes associated with diseases such as gout and metabolic disorders. We test the performance of the device in both physically trained and untrained subjects under exercise and after a protein-rich diet. We also evaluate its utility for gout monitoring in patients and healthy controls through a purine-rich meal challenge. Levels of uric acid in sweat were higher in patients with gout than in healthy individuals, and a similar trend was observed in serum.
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